Controllable NO release from Cu1.6S nanoparticle decomposition of S-nitrosoglutathiones following photothermal disintegration of polymersomes to elicit cerebral vasodilatory activity† †Electronic supplementary information (ESI) available: Experimental section and Fig. S1–S10. See DOI: 10.1039/c6sc02774a Click here for additional data file.
نویسندگان
چکیده
Since the discovery of nitric oxide (NO) as a vasodilator, numerous NO therapies have been attempted to remedy disorders related to pathological vasoconstriction such as coronary artery disease. Despite the advances, clinical applications of NO therapies remain limited mainly because of the low stability of molecular NO donors (and NO molecules), and concerns about the increased oxidative stress and reduced arterial pressure associated with the systemic administration of NO. Here we design a photoresponsive polymersome with nitrosothiols and Cu1.6S nanoparticles in its core and shell, respectively, and demonstrate the photo-triggered release of NO and its vasodilatory activity on zebrafish. Unlike conventional approaches, our design enhances the stability of NO donors and prospectively enables spatiotemporal regulation of NO release, thus minimizing the harmful effects associated with conventional NO therapies. We anticipate that such a strategy will open up new clinical applications of NO and help reveal the complex biological effects of NO in vivo.
منابع مشابه
Controllable NO release from Cu1.6S nanoparticle decomposition of S-nitrosoglutathiones following photothermal disintegration of polymersomes to elicit cerebral vasodilatory activity.
Since the discovery of nitric oxide (NO) as a vasodilator, numerous NO therapies have been attempted to remedy disorders related to pathological vasoconstriction such as coronary artery disease. Despite the advances, clinical applications of NO therapies remain limited mainly because of the low stability of molecular NO donors (and NO molecules), and concerns about the increased oxidative stres...
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Beijing National Laboratory of Molecular Sc Engineering, State Key Laboratory of Applications, Peking University, Beijing, 100 edu.cn; [email protected]; Web: http://w 6275-1708 Jiangsu Key Laboratory for NSLSCS, Scho Nanjing Normal University, Nanjing 210023 Department of Chemistry, Key Laboratory (MOE), State Key Laboratory of Elem Innovation Center of Chemical Science University, Tianjin 30...
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